Predictors of bacterial resistance usingin vitrodynamic models: area under the concentration–time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration
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چکیده
منابع مشابه
Bacterial resistance studies using in vitro dynamic models: the predictive power of the mutant prevention and minimum inhibitory antibiotic concentrations.
In light of the concept of the mutant selection window, i.e., the range between the MIC and the mutant prevention concentration (MPC), MPC-related pharmacokinetic indices should be more predictive of bacterial resistance than the respective MIC-related indices. However, experimental evidence of this hypothesis remains limited and contradictory. To examine the predictive power of the ratios of t...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2015
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkv387